Inhibition of mammalian fatty acid synthetase activity by NADP involves decreased mobility of the 4'-phosphopantetheine prosthetic group.
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چکیده
منابع مشابه
Acyl carrier protein. V. Identification of 4'-phosphopantetheine bound to a mammalian fatty acid synthetase preparation.
Previous investigations from several laboratories have established the sequence of reactions leading to de novo synthesis of fatty acids.'-8 Previous reports have also shown that all these reactions in E. coli occur with the substrates bound as thioesters to an acyl carrier protein (ACP).7-12 Recently, the substrate binding site of ACP has been shown to be the sulfhydryl group of a prosthetic g...
متن کاملProtein turnover and 4'-phosphopantetheine exchange in rat liver fatty acid synthetase.
The rate of turnover of rat liver fatty acid synthetase has been measured in animals tested under steady state conditions. The value obtained for the half-life varied from 71 to 108 hours. The exchange rate of the covalently bound prosthetic group, 4’-phosphopantotheine, with unbound pantothenate compounds was found to be more than an order of magnitude greater than the half-life of the enzyme ...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1987
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)61157-3